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Article

Temporally uncoupled signal and coding joint formation in human V(D)J recombination.

Molecular immunology - 1 Dec 2020

Hsieh Chih-Lin, Okitsu Cindy Y, Lieber Michael R

Abstract excerpt

In vertebrate antigen receptor gene rearrangement, V(D)J recombination events can occur by deletion or by inversion. For deletional events, the signal joint is deleted from the genome. Nearly half of the immunoglobulin light chain genes undergo V(D)J recombination in an inversional manner, and both signal and coding joint formation must occur to retain chromosomal integrity. But given the undetermined amount of...

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Identifiers

PMID: 33157352
DOI: 10.1016/j.molimm.2020.10.010
PMCID: PMC7736249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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