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Article

Characterization of the TGN exit signal of the human mannose 6-phosphate uncovering enzyme.

Journal of cell science - 1 Jul 2005

Nair Prashant, Schaub Beat E, Huang Kai, Chen Xiang, Murphy Robert F, Griffith Janice M, Geuze Hans J, Rohrer Jack

Abstract excerpt

The human mannose 6-phosphate uncovering enzyme participates in the uncovering of the mannose 6-phosphate recognition tag on lysosomal enzymes, a process that facilitates recognition of those enzymes by mannose 6-phosphate receptors to ensure delivery to lysosomes. Uncovering enzyme has been identified on the trans-Golgi network at steady state. It has been shown to traffic to the plasma membrane from where it is...

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PMID: 15976452
DOI: 10.1242/jcs.02434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Characterization of the TGN exit signal of the human mannose 6-phosphate uncovering enzyme.PMID 15976452Read ↗

Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network.Semantic proximity Read ↗

ERGIC-53 and traffic in the secretory pathwaySemantic proximity Read ↗

LYSET facilitates integration of both the N- and C-terminal transmembrane helices/cytoplasmic domains of GlcNAc-1-phosphotransferase.Semantic proximity Read ↗

GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathwaySemantic proximity Read ↗

The lysosomal trafficking regulator "LYST": an 80-year traffic jam.Semantic proximity Read ↗

Sorting Nexins in Protein HomeostasisSemantic proximity Read ↗

ER-associated degradation relying on protein O-mannosylationSemantic proximity Read ↗

The palmitoyltransferase of the cation-dependent mannose 6-phosphate receptor cycles between the plasma membrane and endosomes.Semantic proximity Read ↗

The role of the Golgi apparatus in disease (Review).Semantic proximity Read ↗

Carbohydrate- and conformation-dependent cargo capture for ER-exit.Semantic proximity Read ↗

(Arg)3 within the N-terminal domain of glucosidase I contains ER targeting information but is not required absolutely for ER localization.Semantic proximity Read ↗

Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.Semantic proximity Read ↗

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