Article
Substrate specificity of the gastrin-amidating enzyme.
The Journal of biological chemistry - 25 Jul 1993
Dickinson C J, Daugherty D, Guo Y J, Stadler B, Finniss S, Yamada T
Abstract excerpt
As is the case with many other peptide hormones of the brain and gut, gastrin requires a carboxyl-terminal amide moiety for optimal biological activity. In the structure of progastrin, the carboxyl-terminal Phe of gastrin is followed by the sequence Gly93-Arg94-Arg95, which must be processed sequ...
Topics
- Amides
- Amino Acid Sequence
- Animals
- Cloning, Molecular
- DNA
- Gastrins
- Humans
- Mixed Function Oxygenases
- Molecular Sequence Data
- Multienzyme Complexes
- Mutation
- Protein Precursors
- Protein Processing, Post-Translational