Estrogen induction of TGF-α is mediated by an estrogen response element composed of two imperfect palindromes

doi:10.1016/s0960-0760(96)00118-5

Article

Estrogen induction of TGF-α is mediated by an estrogen response element composed of two imperfect palindromes

1 Nov 1996

Abstract excerpt

To investigate the molecular mechanisms underlying the two- to three-fold induction of human transforming growth factor-alpha (hTGF-alpha) mRNA and two- to five-fold induction of hTGF-alpha protein observed following estrogen treatment of hormone-responsive human breast cancer cell lines, the hTGF-alpha promoter was assayed for ERE-like sequences able to mediate estrogen induction of a heterologous gene....

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