Identification and characterization of a regulated promoter element in the epidermal growth factor receptor gene.

doi:10.1073/pnas.87.19.7536

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Article

Identification and characterization of a regulated promoter element in the epidermal growth factor receptor gene.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1990

Hudson L G, Thompson K L, Xu J, Gill G N

Abstract excerpt

We have identified a 36-base-pair proximal element (-112 to -77 relative to the AUG translation initiation codon) in the epidermal growth factor receptor 5' region that functions as a promoter; mediates inductive responses to epidermal growth factor, phorbol 12-myristate 13-acetate, and cyclic AMP; and acts in an orientation-independent manner. This region functions as an enhancer when transferred to a...

Topics

Base Composition
Base Sequence
Cell Nucleus
Chromosome Deletion
Codon
Cyclic AMP
Epidermal Growth Factor
ErbB Receptors
Gene Expression Regulation
Genes
HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Mutation

Oligonucleotide Probes

Promoter Regions, Genetic

TATA Box

Tetradecanoylphorbol Acetate

Source

Open in PubMed Open full text

Identifiers

PMID: 2170982
DOI: 10.1073/pnas.87.19.7536
PMCID: PMC54782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2170982-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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