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Article

Metabolically-modulated growth and phenotype of the rat heart.

European heart journal - 1 Sept 1992

Rupp H, Jacob R

Abstract excerpt

Heart muscle reacts to work overload and various neuroendocrine stimuli by inducing myocyte growth. A novel type of hypertrophy can be induced in the rat heart by etomoxir, which reduces fatty acid oxidation. This hypoglycaemic drug inhibits the mitochondrial carnitine palmitoyltransferase 1, and thus reduces the long-chain fatty acid uptake of mitochondria; in a compensatory manner, the glycolytic flux is...

Topics

Animals
Cardiomegaly
Energy Metabolism
Fatty Acids
Gene Expression Regulation
Heart Failure
Hemodynamics
Hypertension
Mitochondria, Heart
Muscle Proteins
Phenotype
Rats

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Identifiers

PMID: 1396861
DOI: 10.1093/eurheartj/13.suppl_d.56

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1396861-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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