Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The murine Sm-D autoantigen: multiple genes, genetic polymorphism, evolutionary conservation and lack of intervening sequences in the coding region.

Journal of autoimmunity - 1 Jun 1992

Mitsuda T, Eisenberg R A, Cohen P L

Abstract excerpt

Antibodies to the Sm nuclear antigen are diagnostic of systemic lupus erythematosus (SLE). MRL/Mp-lpr/lpr mice develop a similar illness, and a proportion also develop anti-Sm. To understand better anti-Sm reactivity in this murine model, we have cloned the murine Sm-D autoantigen. One cDNA clone was 517 bp long with an open reading frame of 357 nucleotides, encoding a 13.3 kDa protein of 119 amino acids. At the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Polymerase Chain Reaction

Share to Recombinant Proteins

Source

Identifiers

PMID: 1388635
DOI: 10.1016/0896-8411(92)90143-e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The murine Sm-D autoantigen: multiple genes, genetic polymorphism, evolutionary conservation and lack of intervening sequences in the coding region.PMID 1388635Read ↗

V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice.Semantic proximity Read ↗

Independently derived IgG anti-DNA autoantibodies from two lupus-prone mouse strains express a VH gene that is not present in most murine strains.Semantic proximity Read ↗

Genetic control of anti-Sm autoantibody production in NOD congenic mice narrowed to the Idd9.3 region.Semantic proximity Read ↗

Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice.Semantic proximity Read ↗

Serum SmD autoantibody proteomes are clonally restricted and share variable-region peptides.Semantic proximity Read ↗

Anti-Sm Autoantibodies in Systemic Lupus Target Highly Basic Surface Structures of Complexed Spliceosomal AutoantigensSemantic proximity Read ↗

Restricted CDR3 length of the heavy chain is characteristic of six randomly isolated disease-associated VH J558+ IgM autoantibodies in lupus prone motheaten mice.Semantic proximity Read ↗

Molecular characterization of J558 genes encoding tight-skin mouse autoantibodies: identical heavy-chain variable genes code for antibodies with different specificities.Semantic proximity Read ↗

Both Sm and DNA are selecting antigens in the anti-Sm B cell response in autoimmune MRL/lpr mice.Semantic proximity Read ↗

Three novel SMR1-related cDNAs characterized in the submaxillary gland of mice show extensive evolutionary divergence in the protein coding region.Semantic proximity Read ↗

Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodiesSemantic proximity Read ↗

DNA sequence, genomic organization, and chromosomal localization of the mouse peripheral myelin protein zero gene: identification of polymorphic alleles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.