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Article

Serum SmD autoantibody proteomes are clonally restricted and share variable-region peptides.

Journal of autoimmunity - 1 Feb 2015

Al Kindi Mahmood A, Chataway Tim K, Gilada George A, Jackson Michael W, Goldblatt Fiona M, Walker Jenny G, Colella Alex D, Gordon Tom P

Abstract excerpt

Recent advances in mass spectrometry-based proteomic methods have allowed variable (V)-region peptide signatures to be derived from human autoantibodies present in complex serum mixtures. Here, we analysed the clonality and V-region composition of immunoglobulin (Ig) proteomes specific for the immunodominant SmD protein subunit of the lupus-specific Sm autoantigen. Precipitating SmD-specific IgGs were eluted from...

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Share to Antibodies, Antinuclear
Share to Electrophoresis, Gel, Two-Dimensional

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin G

Share to Immunoglobulin Variable Region

Share to Lupus Erythematosus, Systemic

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Source

Identifiers

PMID: 25577500
DOI: 10.1016/j.jaut.2014.12.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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