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Article

Variation in hemoglobin F production among normal and sickle cell adults is not related to nucleotide substitutions in the gamma promoter regions.

Blood - 1 Jan 1991

Economou E P, Antonarakis S E, Kazazian H H, Serjeant G R, Dover G J

Abstract excerpt

Single nucleotide substitutions in the promoter regions of the A gamma- and G gamma-globin genes have been associated with increased fetal hemoglobin (HbF) production. We wished to determine whether these or other unrecognized substitutions in the gamma promoter regions are responsible for the 20...

Topics

Adult
Anemia, Sickle Cell
Base Sequence
DNA
Fetal Hemoglobin
Genetic Variation
Globins
Haplotypes
Humans
Molecular Sequence Data
Oligonucleotide Probes
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Promoter Regions, Genetic

Reference Values

Source

Identifiers

PMID: 1702028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1702028-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Variation in hemoglobin F production among normal and sickle cell adults is not related to nucleotide substitutions in the gamma promoter regions.PMID 1702028Read ↗

G gamma and A gamma globin genes are identical from -471 of the promoter midway through gamma IVSII in a Benin beta s haplotype associated with elevated fetal hemoglobin.Semantic proximity Read ↗

Promoter region sequence differences in the A and G gamma globin genes of Brazilian sickle cell anemia patients.Semantic proximity Read ↗

The relative importance of the X-linked FCP locus and beta-globin haplotypes in determining haemoglobin F levels: a study of SS patients homozygous for beta S haplotypes.Semantic proximity Read ↗

Sequence change in the HS2-LCR and Ggamma-globin gene promoter region of sickle cell anemia patients.Semantic proximity Read ↗

SAR1a promoter polymorphisms are not associated with fetal hemoglobin in patients with sickle cell disease from Cameroon.Semantic proximity Read ↗

An analysis of fetal hemoglobin variation in sickle cell disease: the relative contributions of the X-linked factor, beta-globin haplotypes, alpha-globin gene number, gender, and age.Semantic proximity Read ↗

Dominant influence of gamma-globin promoter polymorphisms on fetal haemoglobin expression in sickle cell disease.Semantic proximity Read ↗

Molecular genetic studies in black families with sickle cell anemia and unusually high levels of fetal hemoglobin.Semantic proximity Read ↗

Beta-globin gene cluster haplotypes and HbF levels are not the only modulators of sickle cell disease in Lebanon.Semantic proximity Read ↗

Effect of β‐Globin gene cluster haplotype on the hematological and clinical features of sickle cell anemiaSemantic proximity Read ↗

Characterization of the -16C>G sequence variation in the promoters of both HBG1 and HBG2: convergent evolution of the human gamma-globin genes.Semantic proximity Read ↗

α-Globin mutations and Genetic Variants in γ-globin Promoters are Associated with Unelevated Hemoglobin F Expression of Atypical β0-thalassemia/HbE.Semantic proximity Read ↗

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