The Synergy Between Stem Cell Factor (SCF) and Granulocyte Colony-stimulating Factor (G-CSF): Molecular Basis and Clinical Relevance

Abstract excerpt

Stem cell factor (SCF), an essential growth factor in normal hematopoiesis, exerts potent effects when combined with cytokines. In particular, its synergy with granulocyte colony-stimulating factor (G-CSF) results in important biologic responses. These include enhancement of ex vivo long-term expansion of human primitive hematopoietic cells and increased mobilization of peripheral blood progenitor cells (PBPC)...

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