Cytokine manipulation of primitive human hematopoietic cell self-renewal.

doi:10.1073/pnas.94.9.4698

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Article

Cytokine manipulation of primitive human hematopoietic cell self-renewal.

Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 1997

Zandstra P W, Conneally E, Petzer A L, Piret J M, Eaves C J

Abstract excerpt

Previous studies have shown that primitive human hematopoietic cells detectable as long-term culture-initiating cells (LTC-ICs) and colony-forming cells (CFCs) can be amplified when CD34(+) CD38(-) marrow cells are cultured for 10 days in serum-free medium containing flt3 ligand (FL), Steel facto...

Topics

ADP-ribosyl Cyclase
ADP-ribosyl Cyclase 1
Antigens, CD
Antigens, CD34
Antigens, Differentiation
Bone Marrow Cells
Cell Cycle
Culture Techniques
Cytokines
Dose-Response Relationship, Drug
Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Interleukin-3

Membrane Glycoproteins

Membrane Proteins

N-Glycosyl Hydrolases

Phenotype

Stem Cell Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 9114054
DOI: 10.1073/pnas.94.9.4698
PMCID: PMC20787

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9114054-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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