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Article

Cytokine manipulation of primitive human hematopoietic cell self-renewal.

Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 1997

Zandstra P W, Conneally E, Petzer A L, Piret J M, Eaves C J

Abstract excerpt

Previous studies have shown that primitive human hematopoietic cells detectable as long-term culture-initiating cells (LTC-ICs) and colony-forming cells (CFCs) can be amplified when CD34(+) CD38(-) marrow cells are cultured for 10 days in serum-free medium containing flt3 ligand (FL), Steel factor (SF), interleukin (IL)-3, IL-6, and granulocyte colony-stimulating factor. We now show that the generation of these...

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Identifiers

PMID: 9114054
DOI: 10.1073/pnas.94.9.4698
PMCID: PMC20787

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