Synergism of interleukin 6 and 1 alpha,25-dihydroxyvitamin D3 in induction of myeloid differentiation of human leukemic cell lines.

doi:10.1002/jlb.51.3.237

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Article

Synergism of interleukin 6 and 1 alpha,25-dihydroxyvitamin D3 in induction of myeloid differentiation of human leukemic cell lines.

Journal of leukocyte biology - 1 Mar 1992

Duits A J, Dimjati W, van de Winkel J G, Capel P J

Abstract excerpt

Interleukin 6 (IL-6) is a multifunctional cytokine with an important role in immunity. We analyzed the effect of recombinant human IL-6 in combination with 1 alpha,25-dihydroxyvitamin D3 (Vit. D3) on differentiation of the human myeloid leukemic cell lines U937 and HL-60 with respect to alterations in antigen expression and functional activity. Of a panel of antigens analyzed, only CD11b (the alpha chain of CR3),...

Topics

Antigens, CD
Antigens, Differentiation, Myelomonocytic
Calcitriol
Cell Adhesion
Cell Adhesion Molecules
Cell Differentiation
Drug Synergism
Humans
Intercellular Adhesion Molecule-1
Interleukin-6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Leukemia, Myeloid

Lipopolysaccharide Receptors

Macrophage-1 Antigen

Phenotype

Rosette Formation

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1371802
DOI: 10.1002/jlb.51.3.237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1371802-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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