Loss of keratin expression in anaplastic carcinoma cells due to posttranscriptional down-regulation acting in trans.

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Article

Loss of keratin expression in anaplastic carcinoma cells due to posttranscriptional down-regulation acting in trans.

Cancer research - 1 Dec 1992

Paine M L, Gibbins J R, Chew K E, Demetriou A, Kefford R F

Abstract excerpt

Rat keratin K5 and vimentin complementary DNAs have been isolated, identified, and used to study keratin and vimentin expression as markers for cell differentiation. Isologous rat neoplastic epithelial cell lines used were based on a clonal benign epithelial line (A5P/B10) and a clonal anaplastic malignant derivative line (T952/F7). Stable cytoplasmic mRNA was detected for keratin but not vimentin in the benign...

Topics

Animals
Base Sequence
Carcinoma
Cycloheximide
Down-Regulation
Flow Cytometry
Keratins
Molecular Sequence Data
Phenotype
RNA Processing, Post-Transcriptional
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Neoplasm

Rats

Species Specificity

Tumor Cells, Cultured

Up-Regulation

Vimentin

Source

Open in PubMed

Identifiers

PMID: 1384967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1384967-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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