Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines.

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Article

Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines.

Cancer research - 1 Oct 1992

Sommers C L, Heckford S E, Skerker J M, Worland P, Torri J A, Thompson E W, Byers S W, Gelmann E P

Abstract excerpt

We have previously observed that breast cancer cell lines could exhibit either epithelial or fibroblastic phenotypes as reflected by their morphologies and intermediate filament protein expression (C. L. Sommers, D. Walker-Jones, S. E. Heckford, P. Worland, E. Valverius, R. Clark, M. Stampfer, and E. P. Gelmann, Cancer Res., 49:4258-4263, 1989). Fibroblastoid, vimentin-expressing breast cancer cell lines are more...

Topics

Antibodies
Biomarkers, Tumor
Breast Neoplasms
Cell Adhesion Molecules
Cytoskeletal Proteins
Desmoplakins
Doxorubicin
Drug Resistance
Epithelium
Fibroblasts
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intercellular Junctions

Intermediate Filaments

Keratins

Neoplasm Invasiveness

Phenotype

Staining and Labeling

Transfection

Source

Open in PubMed

Identifiers

PMID: 1382837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1382837-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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