Inhibition of tumor invasiveness by 1alpha,25-dihydroxyvitamin D3 coupled to a decline in protein kinase A activity and an increase in cytoskeletal organization.

doi:10.1023/a:1018492525027

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Article

Inhibition of tumor invasiveness by 1alpha,25-dihydroxyvitamin D3 coupled to a decline in protein kinase A activity and an increase in cytoskeletal organization.

Clinical & experimental metastasis - 1 Mar 1997

Young M R, Lozano Y

Abstract excerpt

The capacity of cloned metastatic Lewis lung carcinoma cells (LLC-LN7) to invade through reconstituted basement membrane-coated filters was reduced after incubation with 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3]. This was observed at doses as low as 10(-10) M 1,25(OH)2D3. The 1,25(OH)2D3-treate...

Topics

Animals
Calcitriol
Carcinoma, Lewis Lung
Cell Movement
Cyclic AMP-Dependent Protein Kinases
Cytoskeleton
Dose-Response Relationship, Drug
Mice
Neoplasm Invasiveness
Phenotype
Vimentin

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