Article
An intragenic methylated region in the imprinted Igf2 gene augments transcription.
EMBO reports - 1 Dec 2001
Murrell A, Heeson S, Bowden L, Constância M, Dean W, Kelsey G, Reik W
Abstract excerpt
DNA methylation is usually associated with transcriptional silencing, but in the imprinted mouse Igf2 gene, the paternally expressed copy is methylated in two discrete differentially methylated regions (DMRs). DMR1 is located upstream of the fetal promoters and has been shown to be a methylation sensitive silencer. Here we examine the role of the intragenic DMR2 by gene targeting. In contrast to DMR1, deletion of...
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