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Article

Detection of colorectal cancer K-ras mutations using a simplified oligonucleotide ligation assay.

Journal of immunological methods - 7 Aug 1997

Rothschild C B, Brewer C S, Loggie B, Beard G A, Triscott M X

Abstract excerpt

It has been suggested that some mutations in codons 12 and 13 of the K-ras gene are associated with the progression of colorectal adenomas to carcinomas. The aim of this study was to develop a rapid, colorimetric assay for K-ras point mutations commonly associated with colorectal cancer. K-ras exon 1 was amplified from colorectal tumor DNA and K-ras activating mutations detected using an oligonucleotide ligation...

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Identifiers

PMID: 9328563
DOI: 10.1016/s0022-1759(97)00078-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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