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Article

A method to detect ras point mutations in small subpopulations of cells.

Analytical biochemistry - 15 May 1991

Chen J, Viola M V

Abstract excerpt

Biochemical assays for ras mutations are capable of detecting a mutant allele only if it is present in at least 5% of cells tested. Further, ras mutation assays which utilize the polymerase chain reaction (PCR) are unable to distinguish a ras mutation in a small population of cells from mutations resulting from Taq DNA polymerase base misincorporation. We used a standard restriction fragment length polymorphism...

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Identifiers

PMID: 1679614
DOI: 10.1016/0003-2697(91)90293-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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