Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Threonine in the selectivity filter of the acetylcholine receptor channel.

Biophysical journal - 1 Apr 1992

Villarroel A, Sakmann B

Abstract excerpt

The acetylcholine receptor (AChR) is a cation selective channel whose biophysical properties as well as its molecular composition are fairly well characterized. Previous studies on the rat muscle alpha-subunit indicate that a threonine residue located near the cytoplasmic side of the M2 segment is a determinant of ion flow. We have studied the role of this threonine in ionic selectivity by measuring conductance...

Topics

Amino Acid Sequence
Animals
Biophysical Phenomena
Biophysics
Electric Conductivity
Female
Ion Channels
Magnesium
Molecular Sequence Data
Mutation
Oocytes
Permeability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Rats

Receptors, Cholinergic

Threonine

Xenopus

Source

Open in PubMed Open full text

Identifiers

PMID: 1376167
DOI: 10.1016/S0006-3495(92)81805-2
PMCID: PMC1260517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1376167-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Threonine in the selectivity filter of the acetylcholine receptor channel.PMID 1376167Read ↗

Location of a threonine residue in the alpha-subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel.Semantic proximity Read ↗

Comparative surface accessibility of a pore-lining threonine residue (T6') in the glycine and GABA(A) receptors.Semantic proximity Read ↗

A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution.Semantic proximity Read ↗

Thermal stability of the K+ channel tetramer: cation interactions and the conserved threonine residue at the innermost site (S4) of the KcsA selectivity filter.Semantic proximity Read ↗

Molecular basis of the charge selectivity of nicotinic acetylcholine receptor and related ligand-gated ion channels.Semantic proximity Read ↗

Rings of anionic amino acids as structural determinants of ion selectivity in the acetylcholine receptor channel.Semantic proximity Read ↗

Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region.Semantic proximity Read ↗

Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations.Semantic proximity Read ↗

Altered ionic selectivity of the sodium channel revealed by cysteine mutations within the pore.Semantic proximity Read ↗

The role of a single aspartate residue in ionic selectivity and block of a murine inward rectifier K+ channel Kir2.1.Semantic proximity Read ↗

Location of functional regions of acetylcholine receptor alpha-subunit by site-directed mutagenesis.Semantic proximity Read ↗

A threonine residue in the M2 region of the beta1 subunit is needed for expression of functional alpha1beta1 GABA(A) receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.