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Article

Threonine in the selectivity filter of the acetylcholine receptor channel.

Biophysical journal - 1 Apr 1992

Villarroel A, Sakmann B

Abstract excerpt

The acetylcholine receptor (AChR) is a cation selective channel whose biophysical properties as well as its molecular composition are fairly well characterized. Previous studies on the rat muscle alpha-subunit indicate that a threonine residue located near the cytoplasmic side of the M2 segment is a determinant of ion flow. We have studied the role of this threonine in ionic selectivity by measuring conductance...

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Identifiers

PMID: 1376167
DOI: 10.1016/S0006-3495(92)81805-2
PMCID: PMC1260517

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