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Article

Comparative surface accessibility of a pore-lining threonine residue (T6') in the glycine and GABA(A) receptors.

The Journal of biological chemistry - 22 Nov 2002

Shan Qiang, Haddrill Justine L, Lynch Joseph W

Abstract excerpt

The substituted cysteine accessibility method was used to probe the surface exposure of a pore-lining threonine residue (T6') common to both the glycine receptor (GlyR) and gamma-aminobutyric acid, type A receptor (GABA(A)R) chloride channels. This residue lies close to the channel activation gate, the ionic selectivity filter, and the main pore blocker binding site. Despite their high amino acid sequence...

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Identifiers

PMID: 12239220
DOI: 10.1074/jbc.M208647200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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