Article
Sensitivity and single-strand DNA break repair in Chinese hamster mutants exposed to the carcinogen aflatoxin B1 epoxide and its dichloride model.
Mutation research - 1 May 1992
Martin E A, Waters R
Abstract excerpt
Aflatoxin B1 (AFB1) is a potent carcinogen and mutagen. It requires metabolic activation to be converted to the DNA-binding product aflatoxin B1 epoxide (AFB1-epoxide). A model of this epoxide is aflatoxin B1 dichloride (AFB1Cl2). Both react at the N7 position of guanine to form large adducts. The major adduct formed can either be rapidly removed to leave an apurinic site or can undergo ring opening of the...
Topics
- Aflatoxin B1
- Animals
- Carcinogenicity Tests
- Cell Line
- Cell Survival
- Cricetinae
- Cricetulus
- DNA Damage
- DNA Repair
- DNA, Single-Stranded
- Mutagenicity Tests
- Mutation