Article
The repair of large DNA adducts in mammalian cells.
Mutation research - 1 Mar 1992
Waters R, Jones C J, Martin E A, Yang A L, Jones N J
Abstract excerpt
This paper describes experiments involving the measurement of DNA damage and repair after treatment with 4-nitroquinoline 1-oxide (4NQO) or aflatoxin B1 (AFB1) epoxide in a number of mammalian cell cultures primarily associated with defects in the excision repair of UV-induced DNA damage. The results with transformed derivatives of XP cells belonging to different complementation groups showed that the extent of...
Topics
- 4-Nitroquinoline-1-oxide
- Aflatoxin B1
- Animals
- CHO Cells
- Cell Line, Transformed
- Cell Survival
- Cricetinae
- DNA
- DNA Repair
- Humans
- Mutation
- Ultraviolet Rays