Article
Interaction of stem cell factor and its receptor c-kit mediates lodgment and acute expansion of hematopoietic cells in the murine spleen.
Blood - 1 Jul 1996
Broudy V C, Lin N L, Priestley G V, Nocka K, Wolf N S
Abstract excerpt
The phenotypes of mice that harbor a defect in the genes encoding either stem cell factor (SCF) or its receptor, c-kit, indicate that this ligand/receptor pair is necessary for maintenance of normal hematopoiesis in the adult. Our objective was to determine whether SCF, like erythropoietin, is ne...
Topics
- Anemia, Hemolytic
- Animals
- Antibodies, Monoclonal
- Bone Marrow
- Cell Movement
- Colony-Forming Units Assay
- Erythropoiesis
- Female
- Hematopoietic Stem Cells
- Immunoglobulin G
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Phenotype
- Phenylhydrazines
- Proto-Oncogene Proteins c-kit
- Radiation Chimera
- Rats