Article
Opposite effect of stable transfection of bioactive transforming growth factor-beta 1 (TGF beta 1) versus exogenous TGF beta 1 treatment on expression of 92-kDa type IV collagenase in mouse skin squamous cell carcinoma CH72 cells.
Molecular carcinogenesis - 1 Jun 1997
Rundhaug J E, Park J, Pavone A, Opdenakker G, Fischer S M
Abstract excerpt
We have previously shown that transforming growth factor-beta 1 (TGF beta 1) mRNA is consistently overexpressed in squamous cell carcinomas relative to normal mouse skin. Here we show that 92-kDa type IV collagenase (matrix metalloproteinase) (MMP-9) mRNA was likewise progressively overexpressed...
Topics
- Animals
- Antibodies, Blocking
- Blotting, Northern
- Carcinoma, Squamous Cell
- Collagenases
- Dose-Response Relationship, Drug
- Female
- Matrix Metalloproteinase 9
- Mice
- Mice, Nude
- Mutation
- Papilloma
- RNA, Messenger
- Skin Neoplasms
