Article
Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype.
The Journal of investigative dermatology - 1 Jan 1998
Kawakami T, Ihn H, Xu W, Smith E, LeRoy C, Trojanowska M
Abstract excerpt
Scleroderma fibroblasts exhibit numerous phenotypic differences when compared with healthy skin fibroblasts. Some of these differences, in particular overexpression of collagen type I and other extracellular matrix proteins, parallel the effect of transforming growth factor-beta (TGF-beta) on der...
Topics
- Collagen
- Fibroblasts
- Humans
- Phenotype
- Receptors, Transforming Growth Factor beta
- Scleroderma, Systemic
- Signal Transduction
- Transcription, Genetic
- Transforming Growth Factor beta