Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beta cell expression of endogenous xenotropic retrovirus distinguishes diabetes-susceptible NOD/Lt from resistant NON/Lt mice.

1 Dec 1992

Abstract excerpt

Endogeneous retroviral expression in beta cells is a feature of prediabetes in nonobese diabetic (NOD) mice. The purpose of this study was to characterize the class-specific pattern of retroviral gene expression in NOD/Lt beta cells versus a related, but diabetes-resistant strain, NON/Lt. Electron microscopic comparison of beta cells from both strains indicated low constitutive expression of the intracisternal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Endoplasmic Reticulum Stress and Disease
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1361492
DOI: 10.1172/jci116107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beta cell expression of endogenous xenotropic retrovirus distinguishes diabetes-susceptible NOD/Lt from resistant NON/Lt mice.PMID 1361492Read ↗

The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.Semantic proximity Read ↗

Disease-protected major histocompatibility complex Ea-transgenic non-obese diabetic (NOD) mice show interleukin-4 production not seen in susceptible Ea-transgenic and non-transgenic NOD mice.Semantic proximity Read ↗

MHC-linked protection from diabetes dissociated from clonal deletion of T cells.Semantic proximity Read ↗

Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice.Semantic proximity Read ↗

Maternal environment affects endogenous virus induction in the offspring of type 1 diabetes model non-obese diabetic mice.Semantic proximity Read ↗

The phenotype of lymphoid cells and thymic epithelium correlates with development of autoimmune insulitis in NOD in equilibrium with C57BL/6 allophenic chimeras.Semantic proximity Read ↗

Pathophysiology of the pancreas after oral infection of genetically diverse mice with coxsackievirus B4-E2.Semantic proximity Read ↗

Coxsackievirus can persist in murine pancreas by deletion of 5′ terminal genomic sequencesSemantic proximity Read ↗

Selective up-regulation of intact, but not defective env RNAs of endogenous modified polytropic retrovirus by the Sgp3 locus of lupus-prone mice.Semantic proximity Read ↗

Unusual resistance of ALR/Lt mouse beta cells to autoimmune destruction: role for beta cell-expressed resistance determinants.Semantic proximity Read ↗

Specific destruction of islet transplants in NOD<-->C57BL/6 and NOD<-->C3H/Tif embryo aggregation chimeras irrespective of allelic differences in beta-cell antigens.Semantic proximity Read ↗

Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.