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Article

Structural determinants for binary and ternary complex formation between insulin-like growth factor-I (IGF-I) and IGF binding protein-3.

The Journal of biological chemistry - 5 Jan 1992

Baxter R C, Bayne M L, Cascieri M A

Abstract excerpt

Structural analogs of recombinant human insulin-like growth factor-I (IGF-I), with alterations to each of the B, C, A, and D domains, have been tested for their ability to form binary complexes with IGF-binding protein-3 (IGFBP-3) and ternary complexes with IGFBP-3 and the acid-labile subunit (alpha-subunit). Two functionally distinct regions of IGF-I have been identified. The first, involving residues 3 and 4...

Topics

Binding, Competitive
Carrier Proteins
Epitopes
Humans
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I
Mutation
Recombinant Proteins
Somatomedins
Structure-Activity Relationship

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PMID: 1370451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1370451-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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