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Article

Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex.

Nature communications - 30 Jul 2022

Kim Hyojin, Fu Yaoyao, Hong Ho Jeong, Lee Seong-Gyu, Lee Dong Sun, Kim Ho Min

Abstract excerpt

Insulin-like growth factors (IGFs) have pleiotropic roles in embryonic and postnatal growth and differentiation. Most serum IGFs are bound in a ternary complex with IGF-binding protein 3 (IGFBP3) and acid-labile subunit (ALS), extending the serum half-life of IGFs and regulating their availability. Here, we report cryo-EM structure of the human IGF1/IGFBP3/ALS ternary complex, revealing the detailed architecture...

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Identifiers

PMID: 35907924
DOI: 10.1038/s41467-022-32214-2
PMCID: PMC9338993

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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