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Article

Structure-function studies of an IGF-I analogue that can be chemically cleaved to a two-chain mini-IGF-I.

Protein engineering - 1 Jan 2001

Geddes S, Holst P, Grotzinger J, Gill R, Nugent P, De Meyts P, Wollmer A, Wood S, Pitts J

Abstract excerpt

The structure and biological activities of two disulphide isomers of a C-region deletion mutant of insulin-like growth factor-I (IGF-I) which has an Asn--Gly link engineered at the junction of the A- and B-regions were studied before and after chemical cleavage. Circular dichroism (CD) spectra and binding affinity to IGF binding protein 3 (IGFBP3) indicated that the treatment with hydroxylamine did not disrupt...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11287679
DOI: 10.1093/protein/14.1.61

Genes

IGFBP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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