Article
Interaction between acid-labile subunit and insulin-like growth factor binding protein 3 expressed in Xenopus oocytes.
Journal of biochemistry and molecular biology - 31 Mar 2002
Choi Kyung-Yi, Lee Dong-Hee
Abstract excerpt
The acid-labile subunit (ALS) associates with the insulinlike growth factor (IGF)-I or II, and the IGF binding protein-3 (IGFBP-3) in order to form a 150-kD complex in the circulation. This complex may regulate the serum IGFs by restricting them in the vascular system and promoting their endocrine actions. Little is known about how ALS binds to IGFBP3, which connects the IGFs to ALS. Xenopus oocyte was utilized...
Topics
- Animals
- Biological Transport, Active
- Carrier Proteins
- Endoplasmic Reticulum
- Female
- Glycoproteins
- In Vitro Techniques
- Insulin-Like Growth Factor Binding Protein 3
- Macromolecular Substances
- Mutation
- Oocytes
- Protein Binding
- RNA, Messenger
- Recombinant Proteins
- Xenopus