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Article

Insulin-like growth factor I and its binding proteins: a study of the binding interface using B-domain analogues.

Biochemistry - 30 Nov 1999

Magee B A, Shooter G K, Wallace J C, Francis G L

Abstract excerpt

The biological activity of the insulin-like growth factors (IGF-I and IGF-II) is regulated by six IGF binding proteins (IGFBPs 1-6). To examine the surface of IGF-I that associates with the IGFBPs, we created a series of six IGF-I analogues, [His(4)]-, [Gln(9)]-, [Lys(9)]-, [Ser(16)]-, [Gln(9),Ser(16)]-, and [Lys(9),Ser(16)]IGF-I, that contained substitutions for residues Thr(4), Glu(9), or Phe(16). Substitution...

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PMID: 10625451
DOI: 10.1021/bi9910070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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