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Article

Mutation of three critical amino acids of the N-terminal domain of IGF-binding protein-3 essential for high affinity IGF binding.

The Journal of clinical endocrinology and metabolism - 1 Oct 2001

Buckway C K, Wilson E M, Ahlsén M, Bang P, Oh Y, Rosenfeld R G

Abstract excerpt

The N-terminal domain is conserved in all members of the IGF-binding protein superfamily. Most recently, studies have demonstrated the importance of an IGF-binding protein N-terminal hydrophobic pocket for IGF binding. To examine more critically the amino acids important for IGF binding within the full-length IGF-binding protein-3 protein while minimizing changes in the tertiary structure, we targeted residues...

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PMID: 11600567
DOI: 10.1210/jcem.86.10.7936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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