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Article

Epiderstatin induces the flat reversion of NRK cells transformed by temperature-sensitive Rous sarcoma virus.

Bioscience, biotechnology, and biochemistry - 1 Nov 1992

Osada H, Sasaki M, Sonoda T, Isono K

Abstract excerpt

Epiderstatin is a unique glutarimide antibiotic which was found by screening for inhibitors of the signal transduction of epidermal growth factor (EGF). The antibiotic (0.01 microM) was found to reverse the morphology of NRK cells that were infected with a temperature-sensitive mutant of Rous sarcoma virus (srcts-NRK) from the transformed phenotype to the normal phenotype at the permissive temperature (32 degrees...

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Source

Identifiers

PMID: 1369411
DOI: 10.1271/bbb.56.1801

Genes

NRK
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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