Article
Epiderstatin induces the flat reversion of NRK cells transformed by temperature-sensitive Rous sarcoma virus.
Bioscience, biotechnology, and biochemistry - 1 Nov 1992
Osada H, Sasaki M, Sonoda T, Isono K
Abstract excerpt
Epiderstatin is a unique glutarimide antibiotic which was found by screening for inhibitors of the signal transduction of epidermal growth factor (EGF). The antibiotic (0.01 microM) was found to reverse the morphology of NRK cells that were infected with a temperature-sensitive mutant of Rous sar...
Topics
- Animals
- Antibiotics, Antineoplastic
- Avian Sarcoma Viruses
- Biotechnology
- Cell Cycle
- Cell Division
- Cell Line, Transformed
- Cell Transformation, Viral
- Epidermal Growth Factor
- Mutation
- Oncogene Protein pp60(v-src)
- Phenotype
- Piperidones
- Pyridones
- RNA, Messenger
- Rats
- Temperature