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Article

Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia.

Cancer letters - 30 Sept 1993

Hiramatsu T, Imoto M, Koyano T, Umezawa K

Abstract excerpt

We have screened tropical plant extracts for substances that induce normal morphology in K-rasts-NRK cells. As a result we isolated an anthraquinone compound, damnacanthal, from the chloroform extract of the root of Morinda citrifolia. Damnacanthal induced normal morphology and cytoskeletal structure in K-rasts-NRK cells at the permissive temperature, without changing the amount and localization of Ras. The...

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Source

Identifiers

PMID: 7693328
DOI: 10.1016/0304-3835(93)90259-c

Genes

NRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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