Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia.

doi:10.1016/0304-3835(93)90259-c

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Article

Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia.

Cancer letters - 30 Sept 1993

Hiramatsu T, Imoto M, Koyano T, Umezawa K

Abstract excerpt

We have screened tropical plant extracts for substances that induce normal morphology in K-rasts-NRK cells. As a result we isolated an anthraquinone compound, damnacanthal, from the chloroform extract of the root of Morinda citrifolia. Damnacanthal induced normal morphology and cytoskeletal struc...

Topics

Animals
Anthraquinones
Cell Transformation, Neoplastic
Cytoskeleton
DNA
Genes, ras
Macromolecular Substances
Phenotype
Plant Extracts
Protein Biosynthesis
RNA

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