Article
Nonlethal G0-ts mutant tsJT60 becomes lethal at the nonpermissive temperature after transformation: a hint for new cancer chemotherapeutics.
Cell structure and function - 1 Dec 1990
Tai Y Y, Ninomiya-Tsuji J, Furuoku K, Ogawa N, Ishibashi S, Shiroki K, Segawa K, Tsuchida N, Shibuya M, Ide T
Abstract excerpt
tsJT60 is a nonlethal temperature-sensitive (ts) mutant of a Fischer rat cell line (3Y1) classified as a G0 mutant; i.e., the ts defect is not expressed within the cell growth cycle but is expressed only between the G0 and S phase. tsJT60 clones transformed with oncogenes such as adenovirus E1A,...
Topics
- Adenovirus Early Proteins
- Animals
- Antigens, Polyomavirus Transforming
- Antineoplastic Agents
- Carcinogens
- Cell Division
- Cell Line
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Drug Design
- Genes, Lethal
- Genes, myc