Article
The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.
Nature - 18 Sept 2003
Pintard Lionel, Willis John H, Willems Andrew, Johnson Jacque-Lynne F, Srayko Martin, Kurz Thimo, Glaser Sarah, Mains Paul E, Tyers Mike, Bowerman Bruce, Peter Matthias
Abstract excerpt
Many biological processes, such as development and cell cycle progression are tightly controlled by selective ubiquitin-dependent degradation of key substrates. In this pathway, the E3-ligase recognizes the substrate and targets it for degradation by the 26S proteasome. The SCF (Skp1-Cul1-F-box) and ECS (Elongin C-Cul2-SOCS box) complexes are two well-defined cullin-based E3-ligases. The cullin subunits serve a...
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