Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination.

Developmental cell - 1 Jul 2007

Starostina Natalia G, Lim Jae-min, Schvarzstein Mara, Wells Lance, Spence Andrew M, Kipreos Edward T

Abstract excerpt

In Caenorhabditis elegans, the Gli-family transcription factor TRA-1 is the terminal effector of the sex-determination pathway. TRA-1 activity inhibits male development and allows female fates. Genetic studies have indicated that TRA-1 is negatively regulated by the fem-1, fem-2, and fem-3 genes....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphase-Promoting Complex-Cyclosome
Share to Cullin Proteins
Share to Disorders of Sex Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoprotein Phosphatases

Share to Proteasome Endopeptidase Complex

Share to Sex Determination Processes

Share to Ubiquitin

Share to Ubiquitin-Protein Ligase Complexes

Source

Open in PubMed Open full text

Identifiers

PMID: 17609115
DOI: 10.1016/j.devcel.2007.05.008
PMCID: PMC2064902

Genes

TRA
CUL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17609115-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination.PMID 17609115Read ↗

The C. elegans Sex-Determining GLI Protein TRA-1A Is Regulated by Sex-Specific ProteolysisSemantic proximity Read ↗

Direct protein-protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans.Semantic proximity Read ↗

Somatic sex determinationSemantic proximity Read ↗

PAR-6 levels are regulated by NOS-3 in a CUL-2 dependent manner in Caenorhabditiselegans.Semantic proximity Read ↗

LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline.Semantic proximity Read ↗

Proteasomal ubiquitin receptor RPN-10 controls sex determination in Caenorhabditis elegans.Semantic proximity Read ↗

xol-1, the master sex-switch gene in C. elegans, is a transcriptional target of the terminal sex-determining factor TRA-1.Semantic proximity Read ↗

FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline.Semantic proximity Read ↗

The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene.Semantic proximity Read ↗

E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development.Semantic proximity Read ↗

The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome.Semantic proximity Read ↗

RNA-Regulated TRA-1 nuclear export controls sexual fate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.