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Article

A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila.

PLoS biology - 1 Oct 2007

Arama Eli, Bader Maya, Rieckhof Gabrielle E, Steller Hermann

Abstract excerpt

In both insects and mammals, spermatids eliminate their bulk cytoplasm as they undergo terminal differentiation. In Drosophila, this process of dramatic cellular remodeling requires apoptotic proteins, including caspases. To gain further insight into the regulation of caspases, we screened a large collection of sterile male flies for mutants that block effector caspase activation at the onset of spermatid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17880263
DOI: 10.1371/journal.pbio.0050251
PMCID: PMC1976628

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