Article
Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Molecular cell - 9 Oct 2009
Zhuang Min, Calabrese Matthew F, Liu Jiang, Waddell M Brett, Nourse Amanda, Hammel Michal, Miller Darcie J, Walden Helen, Duda David M, Seyedin Steven N, Hoggard Timothy, Harper J Wade, White Kevin P, Schulman Brenda A
Abstract excerpt
In the largest E3 ligase subfamily, Cul3 binds a BTB domain, and an associated protein-interaction domain such as MATH recruits substrates for ubiquitination. Here, we present biochemical and structural analyses of the MATH-BTB protein, SPOP. We define a SPOP-binding consensus (SBC) and determine structures revealing recognition of SBCs from the phosphatase Puc, the transcriptional regulator Ci, and the chromatin...
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