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Article

A yeast system for stable expression of hepatitis B surface antigen.

Journal of biotechnology - 1 Jun 1990

Shiosaki K, Miyatsu Y, Takahara K, Mizokami H, Hamada F, Matsubara K

Abstract excerpt

We have constructed a yeast strain that has integrated into its chromosomal ribosomal RNA gene site two copies of Hepatitis B virus surface (HBS) antigen gene under the control of the yeast (Saccharomyces cerevisiae) glyceraldehyde-3-phosphate dehydrogenase (GAP) promoter and terminator. The level of expression of HBS gene was low in the strain, but upon chemical and physical mutageneses, in combination with an...

Topics

Chromosomes
Cloning, Molecular
Genes, Viral
Glyceraldehyde-3-Phosphate Dehydrogenases
Hepatitis B Surface Antigens
Mutagenesis
Phenotype
Plasmids
Promoter Regions, Genetic
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1366913
DOI: 10.1016/0168-1656(90)90122-r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1366913-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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