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Article

Selective up-regulation of intact, but not defective env RNAs of endogenous modified polytropic retrovirus by the Sgp3 locus of lupus-prone mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2009

Yoshinobu Kumiko, Baudino Lucie, Santiago-Raber Marie-Laure, Morito Naoki, Dunand-Sauthier Isabelle, Morley Bernard J, Evans Leonard H, Izui Shozo

Abstract excerpt

Endogenous retroviruses are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Because four different classes of endogenous retroviruses, i.e., ecotropic, xenotropic, polytropic, or modified polytropic (mPT), are expressed in mice, we investigated the possibility that a particular class of endogenous retroviruses is associated with the development of murine SLE. We observed >15-fold increased...

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Source

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Identifiers

PMID: 19494335
DOI: 10.4049/jimmunol.0900263
PMCID: PMC2792900

Genes

TLR7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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