Article
Frequent occurrence of Ha-rasl allelic deletion in human ovarian adenocarcinomas.
Tumori - 28 Feb 1991
Viel A, De Pascale L, Toffoli G, Tumiotto L, Miotto E, Boiocchi M
Abstract excerpt
Fourteen human adenocarcinoma specimens were analyzed for somatic abnormalities affecting genes of the ras family. No amplification of the 3 ras genes was detected. Allelic deletion of the Ha-rasl gene (11p15.5) was found to be a very common abnormality in human ovarian adenocarcinomas (4 out of 7 informative cases). However, in these neoplasm deletion of a presumed normal Ha-rasl allele is not a contributory...
Topics
- Adenocarcinoma
- Adult
- Aged
- Alleles
- Chromosome Deletion
- DNA, Neoplasm
- Female
- Gene Amplification
- Genes, ras
- Humans
- Middle Aged
- Mutation