Article
Bilateral Wilms tumor and early presentation in pediatric patients is associated with the truncation of the Wilms tumor 1 protein.
The Journal of pediatrics - 1 Jul 2013
Hu Min, Fletcher Jeffery, McCahon Emma, Catchpoole Daniel, Zhang Geoff Y, Wang Yuan Min, Algar Elizabeth M, Alexander Stephen I
Abstract excerpt
OBJECTIVES: To investigate the frequency of constitutional Wilms tumor 1 gene (WT1) abnormalities in children with bilateral Wilms tumor (WT) and the age of tumor onset in patients with a mutation. STUDY DESIGN: Eight patients with bilateral WT were studied. High-resolution melting and direct sequencing were used to screen for the WT1 gene. Western blotting was performed to determine whether the identified...
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