Article
Bilateral wilms tumor with TP53-related anaplasia.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society - 1 Jan 2000
Popov Sergey D, Vujanic Gordan M, Sebire Neil J, Chagtai Tasnim, Williams Richard, Vaidya Sucheta, Pritchard-Jones Kathy
Abstract excerpt
Wilms tumor (WT) with diffuse anaplasia has an unfavorable prognosis and is often (>70%) associated with mutations in the TP53 gene. Although most WTs are unilateral, 5-10% are bilateral, and they are almost always present with nephrogenic rests. The latter are considered a precursor of WT. Two cases of bilateral WTs with nephroblastomatosis, in which anaplastic changes were detected over a period of time, were...
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