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Article

Cells induced to express a human immunodeficiency virus type 1 envelope gene mutant inhibit the spread of wild-type virus.

Human gene therapy - 1 Aug 1992

Buchschacher G L, Freed E O, Panganiban A T

Abstract excerpt

The feasibility of using a trans-dominant interfering human immunodeficiency virus type 1 (HIV-1) envelope mutant for inducible gene therapy of HIV infection was investigated. Genes encoding wild-type or mutant glycoproteins were introduced into CD4+ cells, where they were stably maintained but n...

Topics

CD4-Positive T-Lymphocytes
Fluorescent Antibody Technique
Gene Expression
Giant Cells
HIV Envelope Protein gp41
HIV-1
HeLa Cells
Humans
Mutation
Precipitin Tests
Virus Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1356022
DOI: 10.1089/hum.1992.3.4-391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1356022-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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