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Article

Vpr is required for efficient Nef expression from unintegrated human immunodeficiency virus type 1 DNA.

Journal of virology - 1 Oct 2007

Poon Betty, Chang Michael A, Chen Irvin S Y

Abstract excerpt

Unintegrated human immunodeficiency virus (HIV) DNA are viral DNA products formed naturally during HIV replication. While the integrated proviral DNA form is transcriptionally active and results in productive infection, unintegrated DNA is also capable of expression of viral RNA and proteins. Previously, we showed that HIV Vpr enhances expression from integrase-defective HIV. Here we show that Vpr activation of...

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Identifiers

PMID: 17652391
DOI: 10.1128/JVI.00947-07
PMCID: PMC2045493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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