Prediction of affected MEN2A gene carriers by DNA linkage analysis for early total thyroidectomy: a progress in clinical screening program for children with hereditary cancer syndrome.

doi:10.1016/0022-3468(92)90332-2

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Article

Prediction of affected MEN2A gene carriers by DNA linkage analysis for early total thyroidectomy: a progress in clinical screening program for children with hereditary cancer syndrome.

Journal of pediatric surgery - 1 Apr 1992

Shimotake T, Iwai N, Yanagihara J, Tokiwa K, Tanaka N, Yamamoto M, Takai S

Abstract excerpt

The gene predisposing to multiple endocrine neoplasia type 2A (MEN 2A) has been assigned to chromosome 10, and affected gene carriers can be identified before the development of associated malignancy in some informative families. We applied these advances in gene mapping to clinical screening for possible pediatric surgery. A family with MEN 2A, consisting of 88 members and their spouses, was studied to test the...

Topics

Adolescent
Adult
Calcitonin
Child
Child, Preschool
DNA
Female
Genetic Carrier Screening
Genetic Linkage
Genetic Testing
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Multiple Endocrine Neoplasia

Pedigree

Pentagastrin

Thyroidectomy

Source

Open in PubMed

Identifiers

PMID: 1355790
DOI: 10.1016/0022-3468(92)90332-2

Genes

RBP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1355790-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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