Article
Predictive DNA testing and prophylactic thyroidectomy in patients at risk for multiple endocrine neoplasia type 2A.
Annals of surgery - 1 Sept 1994
Wells S A, Chi D D, Toshima K, Dehner L P, Coffin C M, Dowton S B, Ivanovich J L, DeBenedetti M K, Dilley W G, Moley J F
Abstract excerpt
BACKGROUND: Missense germ-line mutations in the RET protooncogene are associated with multiple endocrine neoplasia type 2A (MEN 2A). Detection of these mutant alleles in kindred members predicts disease inheritance and provides the basis for preventative thyroidectomy. METHODS: A polymerase chain...
Topics
- Adolescent
- Adult
- Base Sequence
- Calcitonin
- Child
- DNA Mutational Analysis
- DNA, Neoplasm
- Drosophila Proteins
- Female
- Genetic Testing
- Haplotypes
- Humans
- Male
- Molecular Sequence Data
- Multiple Endocrine Neoplasia