Article
Current perspectives on the diagnosis and management of patients with multiple endocrine neoplasia type 2 syndromes.
Endocrinology and metabolism clinics of North America - 1 Mar 1994
Wells S A, Donis-Keller H
Abstract excerpt
Patients with MEN 2A, MEN 2B, and familial non-MEN medullary thyroid carcinoma (MTC) inherit MTC in an autosomal dominant fashion. This malignancy has been diagnosed previously by detecting elevated plasma calcitonin levels, a tumor marker for MTC, following the intravenous administration of secretagogues. Although the study of large pedigrees with MEN 2A, using highly informative flanking markers and linkage...
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