Article
Very early prophylactic thyroid surgery for infants with a mutation of the RET proto-oncogene at codon 634: evaluation of the implementation of international guidelines for MEN type 2 in a single centre.
Clinical endocrinology - 1 Jul 2006
Piolat Christian, Dyon Jean-François, Sturm Nathalie, Pinson Stéphane, Bost Michel, Jouk Pierre-Simon, Plantaz Dominique, Chabre Olivier
Abstract excerpt
OBJECTIVE: Genetic diagnosis available since 1993 established germinal mutations of the RET proto-oncogene at codon 634 as the main cause of inherited medullary thyroid carcinoma (MTC). International guidelines established in 1999 recommend that children with such mutations undergo a total thyroidectomy before age 5, with unspecified cervical neck dissection. Since 1993, only 41 of 275 thyroidectomies reported in...
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